A New Validated Spectrophotometric Method for the Estimation of Rabeprazole Sodium in Tablet Dosage Forms

Abstract

Author(s): Sreenu Domatoti, Sunil babu Koppula

The aim of this work is to develop and validate the derivative spectrophotometric method for determination of theproton pump inhibitorRabeprazolesodiumin pharmaceutical formulations. The technique was applied by using simplereagents 0.5% KmnO4and 2N NaOH solutions.The proposed method for the determination of Rabeprazole sodium showedmolar absorptivity of 23.837x102. Linear regression of absorbance onconcentration gave the equation y= 000087×-0.056witha correlation coefficient of 0.9991. The difference absorption spectrum of Rabeprazole sodium showed maximum absorbanceat 695 nm and obeyed Beer’s law in the concentration range of 20-100g/ml. The proposed method is simple and rapid.