An overview on pharmacological aspects of anti-diabetic activity

Abstract

Author(s): KiranG, Ganesh N. Sharma, Birendra Shrivastava, A. M. S. Sudhakara Babu

Diabetes mellitus is not a single disease but is a group of metabolic disorders affecting a huge number of populations in the world. It is mainly characterized by chronic hyperglycemia, resulting from defects in insulin secretion or insulin action. It is predicated that the number of diabetes person in the world could reach up to 366 million by the year 2030. Even thoughthe cases of diabetes are increasing day by day, except insulin and oral hypoglycemic drugs no other way of treatment has been successfully developed so far. The review also contains brief idea about diabetes mellitus and the experimental screening model with their relevant mechanism and significance mainly used now days. Streptozotocin and alloxan are mainly used for evaluating the ant diabetic activity of a drug. This review containslist of medicinal plants which have been tested for their antdiabetic activity in the streptozotocin induced diabetic rat model. From the available data in the literature, it was found that plant having antidiabetic activity is mainly due to the presence of the secondary metabolite. Thus, the information provided in this review will help the researchers for the development of an alternative methods rather than insulin and oral hypoglycemic agents for the treatment of diabetes mellitus, which will minimize the complication associated with the diabetes and related disorder