Author(s): Gopalakrishnaiah B.* and O. Aniel Kumar
Syzygium cuminileaf extract wasscrutinized indetail for biological properties of anticancer, antimicrobialandantioxidant activities Anticancer activity of S. cumini leaf extract was determined through colorimetric MTT (tetrazolium) assay againstcervicalcancer (HeLa) and human breast adenocarcinoma (MCF-7) cell line and the antimicrobial property of the plant extract revealed by using agar well diffusionagainst sixbacterialand three fungalisolates. Antioxidant activity was characterized using 2,2-diphenyl-1-picrylhydrazyl(DPPH) radical scavenging method. The results of present study indicated that Syzygium cuminileaf extract possessed anticancer activities with half maximal inhibitory concentration (IC50) of 248.2μg/ml. The minimum inhibitory concentration (MIC)values were ranged from 31.25 to 125 mg/l in. The plant extract found to inhibit 30% of DPPH, free radicals. Findings from this study indicated that methanol extract of Syzygium cuminileaf possessed vast potentialas medicinal drug especiallyin drug resistant microorganismsand breast cancer treatment.