Modulation of diabetes and associated complicationsusing ethanolic extract of green fruit of Ficus racemosa Linn. in alloxan induced rats

Abstract

Author(s): Nawale Rajesh B,Mate Ganesh S, Wakure Balaji S

The present study was undertaken to explore the antidiabetic potentials of ethanolic extract of unriped fruits of ficus RecemosaL. (EEFFR)on Alloxan-induced diabetic rats.Hyperglycemia induces the generation of free radicals which can affect antioxidantdefenses and induces oxidative stress leading to diabetes associated complications. The diabetes was induced by intraperitoneal injection of ice-cold aqueous Alloxan monohydrate at dose of 150 mg/kg body weight. After a daily single oral administration ofthe EEFFR at 400 mg/kg for 28 days starting from study protocol, the blood glucose, serum glutamate pyruvate transferase (SGPT), serum glutamate-oxaloacetate transaminase (SGOT), total cholesterol (TC) and triglyceride (TG), total insulin, glycosylated hemoglobin (HbA1c) and C-reactive protein (CRP), superoxide dismutase (SOD) levels were assessed. The results obtained from the study suggested that administration of EEFFR at 400 mg/kg significantly reduced the blood glucose, SGPT, SGOT, TC, TG and CRP, SOD, total insulin and glycosylated hemoglobin. The results obtained were comparableto that of standard glibenclamide. The TC, TG and CRP, HbA1c, SOD and total insulin serum level was significantly altered in diabetic control group but, it was significantly decreased in extract treated groups and standard glibenclamide treated group. During this study protocol, we found that novelty alteration in level of total insulin and HbA1c. The finding obtained suggested that EEFFR act at cellular level modulating the pathways responsible diabetes and associated complications. The results obtained suggest that the EEFFR significant potential for management of diabetes and associated complications.