International Journal of Bio-Pharma Research 2019-01-16T00:45:52+00:00 Managing Editor Open Journal Systems <p>International Journal of Bio-Pharma Research (ISSN: 2287-6898) is an International, Monthly, Open Access,&nbsp;<strong>UGC</strong>&nbsp;<strong>Approved [63681]</strong>&nbsp;journal.</p> <p>IJBPR publishing the finest peer reviewed research in the fields of Biological and Pharmaceutical Sciences on the basis of its novelty, originality, importance, interdisciplinary interest and accessibility. Our objective is to inform authors of the decision on their manuscript (s) within one week of submission after&nbsp;<strong>Rigorous Peer Review</strong>. Following acceptance, a paper will normally be published in the next issue.</p> <p><strong>HIGHLIGHTS</strong></p> <p>&nbsp; &nbsp;UGC Approve Journal&nbsp;<strong>[63681].</strong></p> <p>&nbsp; &nbsp;Rapid publication service with precise review process.</p> <p>&nbsp; &nbsp;Assignment of DOI&nbsp;number with CrossRef.</p> <p>&nbsp; &nbsp;Indexed in worldwide abstracting agencies.</p> <p><strong>Manuscript Submissions</strong>:<br>Authors can submit their manuscript/s prepared in MS Word including Tables and Figures (If Any) at appropriate positions. All communications should be addressed to&nbsp;<strong></strong></p> Prediction of high CPT yielding ecotypes of Nothapodytes nimmoniana (Graham) Mabb. in Western Ghats using Ecological Niche Modeling 2019-01-16T00:45:52+00:00 Cordilea Hannah Joyce Sudandara Priya Kasthuri Bhai N. <p>Camptothecin (CPT) is one of anticancer drug that is widely used for treating various cancers. In India, the drug is primarily sourced from natural habitats of the red listed species <em>Nothapodytes nimmoniana</em>. Ecological niche models are potential tools to define and predict the “ecological niche” of a species that exhibit ecological variations. The predicted ecological niche of a species indicates their survival fitness against Bioclimatic variables. The habitat suitability was predicted using Maxent for different ecotypes of <em>Nothapodytes nimmoniana</em> (Graham.) Mabb. In this study the synonymised populations of <em>N. nimmoniana</em> in the Western Ghats were cogitated as five different ecotypes. The predicted habitat suitability of different ecotypes were evaluated and correlated against CPT content using high performance thin layer chromatography. The study shows a significant positive correlation between the predicted habitat quality and chemical content. The ecotypes growing in sites predicted as highly suitable showed high content of camptothecin compared to those growing in poorly suitable sites. Thereby enabling precise identification of “chemical hot-spots” which will eventually establish a strong foot hold on monoculture of the species, an effort towards conservation.</p> 2018-12-01T00:00:00+00:00 ##submission.copyrightStatement## Isolation and characterization of Arbuscular Mycorrhizal (AM) fungi from the rhizospheric soil of some medicinal plants 2019-01-16T00:45:51+00:00 Dhritiman Chanda Madhumita Dey <p>The present investigation was carried out to estimate the colony forming units of indigenous fungi and to study the diversity and Arbuscular mycorrhizal (AM) of some medicinal plants. The study was also aimed to estimate and isolate the Arbuscular mycorrhizal (AM) spore population from the rhizospheric soil of some important medicinal plants from the Botanical garden of College campus. All the selected medicinal plants i.e., <em>Mentha</em> sp. <em>Ocimum sanctum</em>, <em>Bryophyllum</em> sp. <em>Adhatoda vasica</em>, and <em>Andrographis paniculata </em>showed a very good diversity of rhizospheric soil fungi. The highest number of Colony forming unit (c.f.u) was estimated in <em>Mentha</em> sp (162/10<sup>-1</sup>) followed by <em>Bryophyllum</em> sp. (156/10<sup>-1</sup>), <em>Andrographis paniculata </em>(91/10<sup>-1</sup>), <em>Adhatoda vasica </em>(72/10<sup>-1</sup><em>) </em>and<em> Ocimum sanctum </em>(68/10<sup>-1</sup>). Arbuscular mycorrhizal (AM) spore population was also estimated in all the medicinal plants. The higest number of AM spores was estimated in <em>Andrographis paniculata </em>(121/50gm<sup>-1</sup>) followed by<em> Ocimum sanctum </em>(112/50gm<sup>-1</sup>), <em>Adhatoda vasica </em>(94/50gm<sup>-1</sup><em>), Bryophyllum</em> sp.(89/50gm<sup>-1</sup>) and<em> Mentha</em> sp (75/ 50gm<sup>-1</sup>). The rhizospheric soil fungal diversity including mycorrhizal fungi (<em>Glomus</em> sp.) <span style="text-decoration: line-through;">also</span> was found to be beneficial for increasing the photosynthetic activity and uptake of phosphorus in medicinal plants. Thus, the use of AM inoculum can increase the yield of medicinal plants along with their secondary metabolites to utilize on a sustainable basis as a traditional and herbal medicine for the human welfare.</p> 2019-01-01T14:44:35+00:00 ##submission.copyrightStatement##